The symbiotic microbiota represses the development of allergic inflammation, but the mechanisms involved are unclear. We have shown that intestinal bacteria induce the generation of type 3 T cells (Th17 cells and associated Tregs) that directly regulate pro-allergic type 2 T cells. In the absence of type 3 T cells, anti-helminth, but also pro-allergic responses, are exacerbated. Furthermore, the absence of microbiota during weaning has similar consequences on the deregulation of the immune system that last until adulthood, a phenomenon we name “imprinting”. We propose a model of the immune system where different types of competing and mutually suppressive responses establish a healthy equilibrium. When this equilibrium is lost, because of an absence of one type of microbe in the environment, inflammatory pathology develops. Therapeutic strategies can be designed with the aim to restore immune equilibrium to counter immunopathology.

G. Eberl

Microenvironment & Immunity Unit, INSERM U1224,
Department of Immunology, Institut Pasteur, Paris

Invited par Michel Chignard.

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Centre De Rercherche (CdR) Saint-Antoine
INSERM - UMR S 938

Hôpital St-Antoine

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Tél : +(33) 1 49 28 46 87

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Saint-Antoine Research Center

The CRSA was renewed jointly by Inserm and UPMC as UMRS_938, for 5 years from January 2014 to December 2018.

Last publications

Presentation of the Centre

The CRSA regroups a very strong potential for biomedical research oriented towards both fundamental and translational research. Research is performed in association with the clinical and biological departments of the Saint-Antoine-Tenon-Armand Trousseau hospitals belonging to the same General Hospital Group. The CRSA is composed of 14 accredited research teams and one administrative team located mainly on the site of the Saint-Antoine hospital but also of hospital Armand Trousseau.

Scientific activities

Two scientific interacting orientations are identified: Research in Oncology and Haematology; and Research in Metabolism and Inflammation and Tissue Repair. They include several aspects of translational research : Fundamental; Preclinical; Pathophysiological and Aspects more specifically clinical.

Collective facilities and technological platforms

The Research Centre developed collective facilities (such as L2, L3 laboratories) but is also implicated in UPMC networks (for technologies such as Mass spectrometry, lipidomic and proteomic; Cell and tissue imagery and flow cytometry ; Imagery and functional exploration of small animals)